For CXCL12, in the subgroup aged 50 years and older, an inverse association between rs1144471 and breast cancer was observed under the recessive model (OR=0.35, 95% CI=0.14-0.80) and additive model (OR=0.75, 95% CI=0.59-0.95), while rs3740085 showed a significant association with breast cancer under additive model (OR=1.34, 95% CI=1.05-1.71). Here, CXCL12 is linked to breast cancer.