A study on the combined effects of SNPs in CXCL12 biological axis-related genes revealed that women with the CC/GG genotype in rs2228014-rs1801157 (CXCR4-CXCL12) exhibited a significantly lower risk of breast cancer, whereas there was no relationship between individual SNP and breast cancer (44). The gene discussed is CXCR4; the disease is breast carcinoma.