Analysis of matched Dx and EOI scRNA-seq data along with healthy bone marrow, hematopoietic stem cells, and TARGET AML dataset revealed a novel pAML blast-associated 7-gene signature (i.e., CLEC11A, PRAME, AZU1, NREP, ARMH1, C1QBP, TRH). This evidence concerns the gene ARMH1 and acute myeloid leukemia.