In the current paper, an analysis of differential gene expression using bulk RNA seq data has shown that CDCA7 ranks as the gene showing significant co-expression with ARMH1, during in vitro studies, ARMH1 knockdown leads to downregulation of CDCA7, and knockdown CDCA7 causes downregulation of ARMH1. This finding highlighted the regulatory role of ARMH1 in influencing the expression of CDCA7 in pediatric leukemia, which has never been reported. Here, ARMH1 is linked to leukemia.