Further, survival analysis on CPT1A and mitochondrial fatty acid pathway (MSigDB, GO:0019395) expression in pediatric AML data from the TARGET initiative depicted a significant association between CPT1A (OS P=0.00249, EFS P=0.047) and mitochondrial fatty acid synthesis (OS P=0.000837, EFS P=0.00085) overexpression with poor overall and event-free survival in TARGET-AML cohort (Figure 4I). This evidence concerns the gene CPT1A and acute myeloid leukemia.