Bayan discovered that exosomes secreted by gastric cancer cells carry miR-214-3p into vascular endothelial cells, directly targeting zinc finger protein A20, negatively regulating the iron efflux process key enzyme ACSL4, thereby inhibiting iron efflux in vascular endothelial cells and reducing the efficacy of Apatinib. This evidence concerns the gene ACSL4 and gastric cancer.