As shown in Table 5 and Supplementary Figure 5, no main effects of time or interaction effects of time by group were observed for total numbers of kappa or lambda clonally restricted B-CLL (CD3−/CD5+ CD19+) cells, CD38+ clonally restricted B-CLL cells, or CD49d+ clonally restricted B-CLL cells (all p > 0.05). This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.