NFKB1 and acute kidney injury: In addition, miR-210-3p is a miRNA-mediated signaling pathway in sepsis with AKI via NF-κB. In the previous study stated that miR210HG, which is upregulated in LPS-induced immortalized human proximal tubular epithelial cells (HKC-8), activates the NF-κB pathway by phosphorylating IκBα, facilitating the movement of p65 into the nucleus and mitigating inflammatory responses.