In this study, we hypothesized that patients with a mild form of SCH had significantly higher concentrations of endothelial dysfunction blood markers such as asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1) and endocan (endothelial cell-specific molecule 1), as well as higher concentrations of high sensitivity C-reactive protein (hs-CRP), triglycerides (TG), total cholesterol (CHOL), low density lipoprotein cholesterol (LDL), non-high density lipoprotein cholesterol (non-HDL), and mean platelet volume (MPV) in comparison with the healthy subjects. Here, ESM1 is linked to spindle cell hemangioma.