Barouchos et al. assessed the concentrations of inflammatory indicators (C-reactive protein (CRP), erythrocyte sedimentation rate) and tumor markers (CEA, CYFRA, cancer antigen 125 (CA125), and carbohydrate antigen 19-9 (CA19-9)) in individuals with exacerbation of COPD (COPD-E) (10). The gene discussed is MUC16; the disease is chronic obstructive pulmonary disease.