In turn, reduction of brain Cu levels using dexmedetomidine and/or Cu chelator D-penicillamine resulted in cuproptosis inhibition through improvement of mitochondrial functioning and a significant reduction in LIAS, succinate dehydrogenase complex iron sulfur subunit B (SDHB), DLAT, dihydrolipoamide S-succinyltransferase (DLST), and FDX1 protein expression, all associated with reduction of brain infarction volume in a rat model of in cerebral ischemia/reperfusion (Guo et al., 2023). The gene discussed is SDHB; the disease is Cerebral ischemia.