In addition, many of the differentially methylated and expressed genes identified in this study were reported to be important in rod differentiation and development, such as Nr2e3 and Rho. The reduced expression of Nr2e3 observed in our study, for example, suggests a protective mechanism triggered in degenerating photoreceptor cells to ensure the survival of the retina under stress in RP (Rahman et al., 2020). The gene discussed is NR2E3; the disease is retinitis pigmentosa 1.