EZH2 and hyperinsulinemic hypoglycemia, familial, 4: Multiple chemoresistant models demonstrated suppression of the Schlafen family member 11 (SLFN11), a factor implicated in DNA-damage repair deficiency. In vivo silencing of SLFN11 was linked with marked deposition of H3K27me3 arising by EZH2, within the gene body of SLFN11, which lead to induced local chromatin condensation and gene silencing