It was demonstrated that erythropoietin-producing hepatocellular A2 (EphA2) mediated PRMT1 activation promoted the expression and molecular functions of sex-determining region Y-box 2 (SOX2). PRMT1-mediated methylation was hypothesised to have intensified the expression of SOX2 by stabilising SOX2. It was concluded that EphA2/PRMT1/SOX2 signalling axis regulated cisplatin resistance in SCLC. This evidence concerns the gene SOX2 and small cell lung carcinoma.