In chronic myeloid leukemia (CML) stem cells (LSCs) resistant to imatinib, G9a was also found to be overexpressed and responsible for repressing the transcription of the tumour suppressor SRY-Box Transcription Factor 6 (SOX6) (Zhou M. et al., 2021). Here, SOX6 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.