Therefore, the results suggest that while also inducing higher STAT3 signaling, cryoablation induces STAT5 signaling, which has the potential to inhibit STAT3 oncogenic signaling and lead to reduced tumor cell proliferation, higher sensitivity to chemotherapy (69), and decreased angiogenesis, tumor cell migration, and metastasis (70, 71). The gene discussed is STAT3; the disease is neoplasm.