The resulting mediators and enzymes, such as leukotrienes, prostaglandins, histamine, tryptase, kininogenase, chymase, and toxic basic proteins (MBP; ECP; eosinophil peroxidase, EPO; eosinophil-derived neurotoxin, EDN), are responsible for allergic reactions, including anaphylaxis (180). This evidence concerns the gene RNASE2 and anaphylaxis.