IgE-mediated food allergies have numerous symptoms, including systemic reactions (anaphylaxis), acute or chronic skin symptoms (urticaria, AD, angioedema), respiratory symptoms (asthma, rhinitis, laryngitis, ear inflammation), and gastrointestinal symptoms (abdominal pain, nausea, diarrhea, bloating, loss of appetite, vomiting) (174). The gene discussed is IGHE; the disease is urticaria.