Given the current evidence that IGF1 interacts with M2 - like macrophages and autophagy (M2 - like tumour - associated macrophage - secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway), it is reasonable to speculate that the IGF1 pathway regulated by SCFAs may also have a potential impact on prostate cancer tumor immunity. The gene discussed is IGF1; the disease is prostate cancer.