CCL20 and neoplasm: These SCFAs, on the one hand, enhanced PCa cell migration and invasion by inducing TLR3 - triggered autophagy to further activate NF - κB and MAPK signaling, and on the other hand, reprogrammed the tumor microenvironment through enhanced autophagy by releasing higher levels of the chemokine CCL20, which recruited more macrophage infiltration and simultaneously polarized them to the M2 type (42).