Ferritin (OR, 213.139; 95% CI, 8.604-5279.703; P=0.001), CD3-CD16+CD56+% (OR, 0.011; 95% CI, 0-0.467; P=0.011), anti-EBV-NA-IgG (OR, 57.370; 95%CI, 2.976-1106.049; P=0.007), IL-6 (OR, 71.505; 95%CI, 2.118-2414.288; P=0.017), IL-10 (OR, 213.139; 95% CI, 8.604-5279.703; P=0.001) were identified as independent predictors of EBV-HLH. Here, IL6 is linked to hemophagocytic syndrome.