The reduction in mitochondrial biogenesis is demonstrated in neurodegenerative diseases associated with aging, such as Alzheimer’s disease models (Gong et al., 2010; Wang et al., 2021), levels of PGC1α declined in the Alzheimer’s disease human brain and were correlated with the severity of dementia and Aβ pathology (Qin et al., 2009; Katsouri et al., 2011). Here, PPARGC1A is linked to dementia.