IFNG and infection: In malaria, during the erythrocytic phase, there is intense activation of the immune system, with rapid production of pro-inflammatory cytokines such as IFN-γ by different cells and increased NO to control the infection, directing a type 1 response profile (Th1) (Artavanis-Tsakonas and Riley, 2002; McCall and Sauerwein, 2010; Perez-Mazliah and Langhorne, 2015; Mandala et al., 2021).