SCN10A and neuropathy: In oxaliplatin-induced neuropathy, partial sciatic nerve ligation, and ciguatera poisoning models, it also has been suggested that cold allodynia emerges as the result of unmasking silent cold-sensing neurons connected to nociceptive routes, which occurs as a consequence of the downregulation of Kv1 channels in primary sensory neurons expressing Nav1.8 and CGRPα (MacDonald et al., 2021).