Reinforcing the idea that downregulation of Kv1 channels is behind cold allodynia in several pathologies, MacDonald and colleagues, using in vivo Ca2+ imaging in mice, showed evidence that altered painful cold sensitivity observed in oxaliplatin-induced neuropathy, partial sciatic nerve ligation, and ciguatera poisoning models are related to unmasking silent cold-sensing neurons as a result of Kv1 channels functional reduction in nociceptive neurons expressing Nav1.8 and CGRPα (MacDonald et al., 2021). This evidence concerns the gene SCN10A and ciguatera fish poisoning.