Thus, the results presented here and previous evidence suggest that Kv1.1-1.2 potassium channels represent promising molecular targets in the treatment of painful cold hypersensitivity in neuropathic pain, and that viral-based delivery designed to increase the functional expression of potassium channels underlying IKD may be a potential strategy to revert damage-triggered cold allodynia, not only in orofacial neuropathic pain but also in other sensory alterations where these channels could also have a critical role. Here, KCNA3 is linked to Pain.