Longitudinal clustering has been performed in AD to investigate heterogeneity of topographical differences in MRI.9,76 In addition, tau- and amyloid-PET studies have used cross-sectional data with a probabilistic model for predicting disease subtype and stage.77,78 Future research should explore the progression of glucose metabolism across these subtypes in relation to other imaging modalities. Here, MAPT is linked to Alzheimer disease.