APOE and early-onset autosomal dominant Alzheimer disease: Post-mortem examination revealed homozygosity for APOE ε4 and neuropathological features of intermediate severity Alzheimer’s disease (neuritic plaques, Braak neurofibrillary tangles V/VI) with severe CAA accompanied by perivascular lymphocytic infiltrates, abundant reactive macrophages and fibrinoid degeneration of vessel walls.