DRD2 and psychotic disorder: Bupropion-induced psychosis may be consistent with the dopamine hypothesis of psychosis due to its agonistic effect on dopamine receptors [8]. This hypothesis, which is supported by the inhibitory effect of antipsychotic medications on dopamine D2 receptors, may explain the increased risk of psychotic symptoms with bupropion, which raises dopamine levels between neurons through the inhibition of dopamine reuptake [8].