CAPN3 and myopathy: In recent years, CAPN3 variants have been identified in families with an autosomal dominant (AD) myopathy, typically characterized by a milder phenotype and later onset (LGMDD4), challenging the exclusive recessive inheritance pattern of this disorder (Vissing et al., 2016; Vissing et al., 2020; Martinez-Thompson et al., 2018; Cerino et al., 2020a; González-Mera et al., 2021; Cerino et al., 2020b).