demonstrated that inhibiting FAK led to a reduction of the contractile force and membrane tension properties of tumor cells and ECM stiffness, which significantly facilitated CRISPR gene editing in tumor cells by increasing the endocytosis and tumor penetration of lipid nanoparticles.[52] On the other hand, NPs could regulate the intracellular response of cancer cells to mechanical signals from the ECM and influence cancer progression, thereby diminishing the likelihood of tumor dissemination resulting from degradation of the ECM. The gene discussed is PTK2; the disease is neoplasm.