Notably, previous research has demonstrated that exosomes derived from primary cancers that contain integrin‐related proteins can be taken up by distant metastatic tissues, and integrin‐related proteins play important roles in recognition of cancer cells and progression of cancer.[43] The relevant animal experiments in this study demonstrated that the treatment outcomes were better in the HuCCT1M@NPs+siABHD11‐AS1@BAPN group than in the other groups, that is, the HuCCT1‐CDX tumor size was significantly reduced in the HuCCT1M@NPs+siABHD11‐AS1@BAPN group. This evidence concerns the gene PTGDR and neoplasm.