LOX and colorectal cancer: A recent study demonstrated that degradation of hyaluronan in vivo using a clinical dose of hyaluronidase suppressed tumorigenesis of mesenchymal colorectal cancer and its metastasis to the liver.[47] BAPN is a specific LOX inhibitor, and its mechanism of action involves competitive binding to the active site of the LOX enzyme, preventing it from oxidizing amino acid residues.