Extracellular matrix (ECM) stiffness influences phenotypes of primary liver cancers, and the YAP1/ABHD11‐AS1/STAU2/ZYX/p‐YAP1 pathway is a useful entry point to delve into specific mechanisms of mechanical signal transduction from the ECM in intrahepatic cholangiocarcinoma and corresponding effects on cancer progression. The gene discussed is ZYX; the disease is cancer.