STING1 and acute kidney injury: This interaction induces conformational changes in STING, triggering downstream signaling cascades, including the activation of IRF3 and the phosphorylation and nuclear translocation of NF‐κB.[11] In eukaryotic cells, the nucleus and mitochondria are the exclusive compartments for DNA, both of which undergo intense oxidative stress during AKI, leading to the production of substantial oxidative‐DNA fragments.