Our findings also underscores distinct responses of MDMs and DCs from healthy individuals compared with those with T1D when treated with BL001 underscoring the multifaceted role of LRH1/NR5A2 activation in shaping the immune microenvironment towards an anti‐inflammatory and regenerative state pending the health status of the individual. The gene discussed is NR5A2; the disease is type 1 diabetes mellitus.