Taken together, these results suggest that pharmacological activation of LRH‐1/NR5A2 mitigates PBMCs‐induced β‐cells apoptosis likely via decreased CD8+ cytotoxic T‐cells and reduced IFNγ, a key cytokine contributing to the triggering and amplification of autoimmunity.84 This evidence concerns the gene CD8A and Autoimmunity.