A comparison of DEGs between healthy and T1D BL001‐treated M10 and M1 macrophages showed minimal overlap of common DEGs (Figure S3C,D) resulting in distinct KEGG enrichment pathways being affected by BL001 (Figures 2C,D and S3E,F) further emphasising that the molecular alterations induced by the pharmacological activation of LRH‐1/NR5A2 are dependent of the health status. This evidence concerns the gene NR5A2 and type 1 diabetes mellitus.