In line with this idea, BL001 also prevented PBMCs allogenic‐induced hiPSC‐derived islet organoid cell apoptosis and decreased INS mRNA expression; this correlated with decreased secretion IFNγ, a key cytokine released by cytotoxic CD8+ T‐cells that causes β‐cell dysfunction and increased HLA class I expression and chemokine release, thus attracting cytotoxic CD8+ T‐cells and amplifying autoimmunity.84 This evidence concerns the gene CD8A and Autoimmunity.