A tumorigenic chimeric transcript, RAD51AP1-DYRK4, enhances the activation of MEK/ERK signaling and increases the invasiveness of ductal mammary carcinomas (Liu et al, 2021) and hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk (Qiao et al, 2023). This evidence concerns the gene DYRK4 and lung cancer.