The elevated median copy number of H3-5 in comparison to GAPDH suggests the presence of 12p gain in both germ cell neoplasia in situ (GCNIS) (median fold change = 5.79) and in seminoma tumor samples (median fold change = 3.93), when normal testicular samples (n = 3) were compared with GCNIS (n = 10) and seminomas (n = 10) (Fig. 4C). The gene discussed is GAPDH; the disease is seminoma.