Briefly, thrombocytopenia showed a significant negative association with PDGF-A and B, Amyloid-beta precursor protein (APP), SLAM family member 5 (CD84), Transforming growth factor beta-1 (LAP-TGF-beta-1), Plasminogen activator inhibitor 1 (PAI), Syndecan-4 (SDC4) and Thrombospondin-2 (THBS2), all proteins known to be involved in ROP development.36–40. This evidence concerns the gene SERPINE1 and retinopathy of prematurity.