TREM1 and infection: EV‐D68‐induced upregulation of TREM‐1 was observed. Furthermore, blocking the TREM1 pathway using LP17, a specific inhibitor, reduced the activation of the p38 MAPK signaling cascade. This indicates that TREM‐1 primarily facilitates the phosphorylation of p38 MAPK. Notably, LP17 treatment, which inhibits TREM‐1, also suppressed viral replication and infection.