CD274 and neoplasm: Importantly, TME status remains predictive of overall survival of first line ICI-treated patients even after accounting for confounding effects of tumor stage, tissue type (primary vs metastatic) and PDL1 scores (HR = 0.57 [95% CI: 0.38-0.85], Cox proportional hazards p-value: 0.006; Supplementary Fig. 10) and restricting the analysis to patients with needle biopsy specimens (log-rank test p-value 0.0034, HR = 0.54 [95% CI: 0.36-0.82], Supplementary Fig. 11).