Rather, PPM1D overexpression activates BAX expression and apoptosis in p53-null osteosarcoma SAOS2 cells by removing inhibitory phosphorylation of the BAX-regulating transcription factor RUNX2 and by reducing anti-apoptotic BCL-XL levels through suppression of the NF-κB pathway [55]. This evidence concerns the gene BAX and osteosarcoma.