Additionally, we incorporated in-house experiments of ER RIME (Rapid Immunoprecipitation Mass Spectrometry of Endogenous proteins)61 proteomic profiling across 16 ER+ cancer cell lines (15 breast cancer and one endometrial cancer) representing an unbiased survey of ER-associated protein complexes using IP-mass spectrometry. Here, ESR1 is linked to breast carcinoma.