In view of ATF4 ectopically expressed in STR/SN of PD patients, here, ATF4 was determined in MPP+-induced BV2 cells, we found that ATF4 was increased in MPP+-induced BV2 cells or SN of MTPT-treated mice, upregulated ATF4 was coincided with our bioinformatics analysis. Here, ATF4 is linked to Parkinson disease.