CDK5RAP2 and Cockayne syndrome: Although we used the same number of hiPSC (Healthy control, CDK5RAP2-mutated, and Cockayne syndrome) to generate Hi-Q brain organoids, age-matched (30-day old organoids) CDK5RAP2 patient-derived organoids (Hereafter CDK5RAP2 organoids) were smaller in size.