INS and heart disorder: Medications could alter the expressions of several EV markers; to address this issue, we performed a sub-analysis in groups of patients with at least one CV risk factor, OD and/or established cardiac disease, and after an acute CV event, after stratification for treatment with antihypertensive medications, lipid-lowering drugs, hypoglycemic agents (including insulin), antiplatelets, and anticoagulants (Supplementary Table S24).