We then performed a multivariate analysis adjusted for both age and sex (Supplementary Fig. S5E, G, I and Supplementary Table S16), which identified CD11c, CD31, and HLA-II, as independent predictors of a CV risk factor, CD20, CD42a, CD49e, CD62P, and HLA-II as predictors of OD/cardiac disease, and CD31, CD42a, CD44, CD49e, and CD62P, as predictors of a CV event. The gene discussed is ITGA5; the disease is heart disorder.