SELP and heart disorder: In the detection of OD and cardiac disease, HLA-II reached a quite reliable performance only in patients with an age equal or higher than 70 years (AUC = 0.880), while CD62P, CD42a, and CD31 were highly accurate from 60 years of age (AUC up to 0.979–0.988); again, low levels of CD31 suggested the presence of CV risk indicators (in this case OD and/or cardiac disease) in younger patients (<40 years; AUC = 0.967; Supplementary Table S8).