After stratification for sex (Supplementary Tables S10–S15), EV profiling showed a slightly higher expression of CD20, CD40, CD44, CD86, and CD133/1 in females as compared to male HC (Supplementary Fig. S5A); the same trend was observed in subjects with at least one CV risk factor (Supplementary Fig. S5B), while no significant differences were observed in patients with OD and/or cardiac disease, and in those after an acute CV event (Supplementary Fig. S5C, D). The gene discussed is CD40; the disease is heart disorder.