In addition to gender (male predominance) and race (mainly a disease of Caucasian individuals), established risk factors for EoE include atopy and other allergic conditions (e.g., allergic rhinitis, elevated serum immunoglobulin E [IgE] to common aeroallergens, asthma, atopic dermatitis and pollen food allergy syndrome). The gene discussed is IGHE; the disease is eosinophilic esophagitis.