To decipher the cellular state and function of macrophages in the process of intestinal-type gastric adenocarcinoma carcinogenesis, we reclustered all of the macrophages into five clusters, including macrophage_IL1B, macrophage_CHI3L1, macrophage_CXCL3, macrophage_IFIT3 and macrophage_FOLR2 (Fig. 2A and Fig. 2B). The gene discussed is CHI3L1; the disease is gastric adenocarcinoma.