The ALT displays focal amplification of 12q14-15 (representing MDM2 and CDK4) with an otherwise stable genome and no copy number alterations in BRCA2, BRIP1, ATR or APC. In the ccRCC specimen, copy gains in BRCA2, BRIP1, ATR and APC can be observed within the context of a tetraploid tumour. The gene discussed is BRCA2; the disease is nonpapillary renal cell carcinoma.