Univariate Cox regression analysis, followed by LASSO regression identified 10 key metabolism-related proteins significantly associated with reproductive outcomes in PCOS: ACSL5, ANPEP, CYB5R3, ENOPH1, GLS, GLUD1, LDHB, PLCD1, PYCR2, and PYCR3. The gene discussed is ACSL5; the disease is polycystic ovary syndrome.