Furthermore, immune checkpoint genes, such as TNFRSF14, TNFRSF4, TNFSF4, BTN2A1, and BTN2A2, are suggested to have a strong correlation with disulfidptosis and may play an essential role in enhancing tumor immunity (Chen et al. 2023a, b). The gene discussed is TNFRSF4; the disease is neoplasm.