Although it has been documented that CQ can improve psoriasis like dermatitis induced by imiquimod by blocking the activation of NLRP3 inflammasome (Chen et al. 2022a), whether CQ has a targeting inhibitory effect on NLRP3 inflammasome and what are the key groups by which CQ exerts its inhibitory effect, and whether CQ exhibits therapeutic effects in multiple NLRP3-driven diseases have not been elucidated. This evidence concerns the gene NLRP3 and psoriasis.