Therefore, this study focuses on the ability of CQ to specifically inhibit NLRP3 inflammasome activation in human and murine derived macrophages, and evaluates the ameliorative effects of CQ in the model of LPS-induced peritonitis, dextran sodium sulfate (DSS)-induced colitis, and monosodium urate (MSU)-induced gouty arthritis in mice. The gene discussed is NLRP3; the disease is colitis.