Thyroid storm is an acute, life-threatening complication of hyperthyroidism that presents with multisystem involvement and is associated with a significant mortality rate of 8% to 25%.20 Goals of treatment are to control increased adrenergic tone, achieve euthyroidism quickly and safely by reducing thyroid hormone synthesis, block thyroid hormone release, inhibit peripheral conversion of T4 to T3, and reduce enterohepatic recycling of thyroid hormone (Table 4).20,75–77. This evidence concerns the gene TG and thyroid crisis.