Particularly, intravesical instillation of VB-85247 induced elevated gene expression in the tumor-bearing bladders for IFNβ, CXCL10, CCL5, IL6, and TNFα at 4 hours after treatment, with the fold-induction of gene expression in the order of IFNβ > CXCL10 > CCL5 > IL6 > TNFα (Fig. 2A). This evidence concerns the gene TNF and neoplasm.