CD4 and infection: In conclusion, this study provides insight into the role of cDC1s in the induction of food-specific pTregs and oral tolerance, and uncovers a mechanism by which infection can disrupt this pathway to impair oral tolerance by exclusion of cDC1 and Rorγt+ APCs from antigen presentation to CD4+ T cells in draining LNs, rather than by their reprogramming (47, 48).