Beclin1, P62, and LC3B proteins in the myocardium of animals in the sham-operated group had a certain amount of basic expression; Compared with the sham-operated group, the expression of Beclin1 protein was significantly increased, the expression of P62 protein was decreased, the expression of LC3B protein was significantly increased, and the ratio of LC3B (II/I) was increased in heart failure group (P<0.05). The gene discussed is MAP1LC3B; the disease is heart failure.