Compared with the sham operation group, the expression of Beclin1 and LC3B (II/I) protein in the heart failure group was significantly increased (P<0.05), and the expression of P62 protein was decreased (P<0.05), suggesting that the autophagy level of the animal cardiac myocytes was increased during heart failure, which was similar to the above research results. Here, BECN1 is linked to heart failure.