BECN1 and cerebral cavernous malformation: After CCM treatment, the expression of Beclin1 and LC3B (II/I) protein in myocardial tissue of heart failure animals decreased (P<0.05), and the expression of P62 protein increased (P<0.05), suggesting that the improvement of cardiac function of heart failure animals by CCM may be related to the inhibition of autophagy of cardiac cells by CCM.