This study found that the expression of Bcl-2, ALDH2 mRNA in the heart failure group was significantly lower than that in the sham operation group (P<0.05), and the expression of Bax, Caspase-3 mRNA was significantly higher (P<0.05), suggesting that the apoptosis activity of myocardial cells in the heart failure group was increased. The gene discussed is ALDH2; the disease is heart failure.