After CCM treatment, the expression of Beclin1 and LC3B (II/I) protein in myocardial tissue of heart failure animals decreased (P<0.05), and the expression of P62 protein increased (P<0.05), suggesting that the improvement of cardiac function of heart failure animals by CCM may be related to the inhibition of autophagy of cardiac cells by CCM. This evidence concerns the gene BECN1 and heart failure.