Compared with the sham-operated group, the density of LC3 immunofluorescence staining spots in the myocardial tissue of rabbits in the heart failure group increased, suggesting that autophagy activity of myocardial cells in the animals increased after heart failure; Compared with the heart failure group, the LC3 immunofluorescence staining in the myocardial tissue of animals after CCM intervention decreased, and the density of positive fluorescent spots decreased. The gene discussed is MAP1LC3A; the disease is heart failure.