CXCL12 was unable to induce EMT in IGROV1 CXCR4-KO (S4A and S4B Fig), confirming the specific role of CXCR4 to promote CXCL12 mediated EMT in ovarian cancer and the ability of R54 in hinder this process. This evidence concerns the gene CXCR4 and ovarian cancer.