CXCL12 and ovarian carcinoma: To evaluate the impact of R54 in ovarian cancer cells sensitivity to chemotherapy, CAOV3, OVCAR8 and IGROV1 cells were treated with cisplatin (CDDP) and paclitaxel (PTX) and CXCL12 dependent growth was evaluated in the presence of R54 (Fig 5A and S6A Fig).