The strength and novelty of the present work is the combined utilization of WGCN, enrichment, PPIN, and FFL analyses which manage to pick up KLF7, CAMP responsive element binding protein 1 (CREB1), miR-328-3p responsible for MS progression and may prove to be robust diagnostic as well as predictive biomarkers for its early diagnosis and treatment. This evidence concerns the gene KLF7 and myeloid sarcoma.