The strength and novelty of the present work is the combined utilization of WGCN, enrichment, PPIN, and FFL analyses which manage to pick up KLF7, CAMP responsive element binding protein 1 (CREB1), miR-328-3p responsible for MS progression and may prove to be robust diagnostic as well as predictive biomarkers for its early diagnosis and treatment. The gene discussed is CREB1; the disease is myeloid sarcoma.