Finally, the vitro experiments demonstrated that BBR could significantly reduce aortic plaque area, alleviate hepatic lipid deposition, and downregulate the transcription levels of MNDA, PIM2, DUSP6, CCL3, C5AR1, and FPR1, thereby improving the pathological state of AS combined with NAFLD. The gene discussed is C5AR1; the disease is metabolic dysfunction-associated steatotic liver disease.