Finally, the vitro experiments demonstrated that BBR could significantly reduce aortic plaque area, alleviate hepatic lipid deposition, and downregulate the transcription levels of MNDA, PIM2, DUSP6, CCL3, C5AR1, and FPR1, thereby improving the pathological state of AS combined with NAFLD. Here, DUSP6 is linked to metabolic dysfunction-associated steatotic liver disease.