Notably, we observed that high saturated fat intake was associated with increased IL-6 levels (OR = 2.03, 95% CI = 1.00–4.11, p < 0.047), whereas high total fat intake was associated with increased leptin levels (OR = 2.14, 95% CI = 1.12–3.38, p < 0.021) in participants with obesity. The gene discussed is IL6; the disease is Obesity.