To define the protective role of Muc17 in the murine distal colon, cohoused Muc17fl/fl and Muc17ΔIEC littermates were subjected to 7-day ad libitum administration of dextran sodium sulfate (DSS), a chemically induced model of human ulcerative colitis (Supplemental Figure 8A). This evidence concerns the gene MUC17 and ulcerative colitis.