TWIST1 (a basic helix-loop-helix transcription factor) reprograms EMT by repressing the expression of E-cadherin and TJP1 (Nagai et al., 2016; Yang et al., 2004) and simultaneously inducing several mesenchymal markers, typically VIM (Bulzico et al., 2019; Meng et al., 2018; Nagai et al., 2016; Yang et al., 2004), which is a pivotal predictor of CRC progression (Vesuna et al., 2008; Yang et al., 2004; Yusup et al., 2017; Zhu et al., 2015). The gene discussed is NEUROD1; the disease is colorectal carcinoma.