TWIST1, a basic helix-loop-helix transcription factor, represses the expression of E-cadherin and TJP1 and induces several mesenchymal markers including vimentin, which is a pivotal predictor of CRC progression (Nagai et al., 2016; Yang et al., 2004; Bulzico et al., 2019; Meng et al., 2018; Nagai et al., 2016; Vesuna et al., 2008; Yang et al., 2004; Yusup et al., 2017; Zhu et al., 2015). The gene discussed is NEUROD1; the disease is colorectal carcinoma.